Amprion Patent Information

Amprion continues to build its intellectual property surrounding the company's proprietary methodology for highly sensitive detection of misfolded proteins and amyloid-like aggregates. Recently, fundamental patents have issued in key geographies which expand our extensive coverage in the EU and UK. The issued patents apply broadly to the methodology known alternatively as seed amplification assay (SAA), protein misfolding cyclic amplification (PMCA) or real-time quaking-induced conversion (RT-QuiC).

Logo for Amprion Diagnostics, which has patents for seed amplification assay (SAA), PMCA, and RT-QuiC

Global Protection for Breakthrough Synuclein Technology

Amprion’s owned or exclusively-licensed ɑ-synuclein portfolio is particularly extensive. The portfolio currently includes multiple allowed and/or issued patents in numerous global regions. Amprion also has an issued U.S. patent and pending applications worldwide directed to Amprion’s proprietary ɑ--synuclein SAA substrate plus other key components needed for robust, reliable and reproducible performance of the technology

The Amprion products are protected by patents in the U.S. and elsewhere. This patent disclosure is provided to satisfy the virtual patent marking provisions of various jurisdictions, including the virtual patent marking provisions of the America Invents Act. The Amprion products may be protected by one or more patents listed below. In accordance with Section 287(a) of Title 35 of the United States Code, the reader ishereby placed on notice of Amprion, Inc.’s rights in the United States patents listed on this site and associated with Amprion’s products:

Detection of Misfolded Alpha Synuclein Protein – US Patent No. 10,989,718; EP Patent No. EP3191599B1; AU Patent No. AU2015314783B2; CA Patent No. CA2960830C; JP Patent Nos. JP6980953B2, JP7104943B2; IL Patent Nos. IL251052B, IL291809B; KR Patent No. KR102448128B1; IN Patent No. IN441373B; MX Patent No. MX393139B; SG Patent Nos. SG11201701953RB, SG10202008464UB; other patents pending.

Alpha-Synuclein Detection Using Beads – US Patent Nos. 11,079,396, 11,959,927; KR Patent No. KR102793756B1; MX Patent No. MX416383B; other patents pending.

Alpha-Synuclein Detection Assay and Method for Diagnosing Alpha-Synucleinopathies – US Patent Nos. 11,099,197, 11,360,103, 12,078,643; EP Patent No. EP3482209B1; HK Patent No. HK40007562A1; AU Patent No. AU2017292377B2; CN Patent No. CN109496272B; KR Patent No. KR102323688B1; JP Patent No. JP6980750B2; other patents pending.

Alpha-Synuclein Substrates and Methods for Making and Using the Same – US Patent Nos. 11,254,718, 11,970,520; MX Patent No. MX417454B; other patents pending.

Inert Matrices for Qualitative and Semi-Quantitative Seed Amplification Assays – US Patent No. 12,220,445; other patents pending.

Discriminating Parkinson’s Disease from Multiple System Atrophy Using Alpha- Synuclein PMCA – US Patent No. 12,265,089; other patents pending.

Detection of Misfolded Tau Protein – US Patent No. 11,249,092; CN Patent No. CN110869763B; IL Patent No. IL270612B; JP Patent No. JP7308154B2; MX Patent No. MX418141B; other patents pending.

Detection of Misfolded Amyloid Beta Protein – US Patent No. 9,910,049; other patents pending.

Methods for Estimating Prion Concentration in Fluids and Tissue by Quantitative PMCA – US Patent No. 10,215,763

Patent List by Country

Amprion, Inc. holds the rights to the following patents.

Other patents may be pending.

U.S. Patents
9,910,049
10,215,763
10,989,718
11,079,396
11,099,197
11,249,092
11,254,718
11,360,103
11,959,927
11,970,520
12,078,643
12,220,445
12,265,089

Australian Patents
AU2015314783B2
AU2017292377B2

Canadian Patent
CA2960830C

Chinese Patents
CN109496272B
CN110869763B

European Patents
EP3191599B1
EP3482209B1

Hong Kongese Patent
HK40007562A1

Indian Patent
IN441373B

Israeli Patents
IL251052B
IL270612B
IL291809B

Japanese Patents
JP6980750B2
JP6980953B2
JP7104943B2
JP7308154B2

Korean Patents
KR102448128B1
KR102793756B1
KR102323688B1

Mexican Patents
MX393139B
MX416383B
MX417454B
MX418141B

Singaporean Patents
SG11201701953RB
SG10202008464UB