Biology: The Power to Know Beyond the Symptoms

Symptoms only tell part of the story. The SAAmplify-αSYN test reveals the biology early and accurately, helping guide treatment decisions when it matters most.

Lab technician running an alpha-synuclein seed amplification assay (𝛼-SYN-saa) to look for misfolded alpha synuclein proteins.

From Suspected to Detected

The SAAmplify-αSYN test (formerly SYNTap) is the first and only commercially available test that detects misfolded α-synuclein protein—the biological hallmark of synucleinopathies including Lewy body disease, Parkinson's disease, and many cases of atypical Alzheimer's disease. By directly measuring these protein aggregates in cerebrospinal fluid, we provide empirical evidence of pathology that previously could only be identified at autopsy.

Symptom-based diagnosis often overlooks the underlying biology: many neurodegenerative disorders involve contributing ɑ-synuclein pathology. Unlike labels based solely on clinical presentation, the SAAmplify-ɑSYN test shows you what's happening at the molecular level. Amprion gives you power to know your ɑ-synuclein status, enabling more confident clinical decisions and better patient outcomes.

Unmatched Scientific Validation

Our technology isn't just innovative—it's extensively validated through rigorous scientific research and real-world clinical application. The SAAmplify-ɑSYN test's accuracy has been demonstrated through multiple peer-reviewed publications. This robust evidence—including third-party studies with blinded samples and autopsy-confirmation—is empowering clinical decision-making, research advancement, and ultimately, patient care.

400

autopsy confirmations

1,200+

scientific publications

20,000

samples

What Certainty Means for Care

Moving beyond 'probable' diagnosis doesn't just validate - it transforms. Here's how biological confirmation of the presence of misfolded α-synuclein proteins impacts everyone in the care journey.

For Physicians

✓ Proven Biological Confirmation
‍Move beyond symptom-based diagnosis to biological certainty
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✓ Earlier Diagnosis Opportunity
Detect pathological changes before clinical manifestation

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✓ Better Treatment Planning
Make informed decisions based on confirmed pathology

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✓ Reduced Diagnostic Uncertainty
Eliminate the 'probable' from your diagnosis

For Healthcare

✓ Reduced Diagnostic Costs
‍Eliminate unnecessary tests and treatments
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✓ Better Resource Utilization
Target resources to confirmed conditions

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✓ Improved Treatment Targeting
Match treatments to pathology
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✓ Enhanced Trial Selection
Identify suitable candidates for clinical trials

For Patient

✓ Faster Path to Answers
Skip years of symptom monitoring
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✓ More Accurate Diagnosis
Know exactly what you're dealing with

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✓ Better Informed Treatment
Receive treatment specific to your biology
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✓ Quality of Life Planning
Make informed decisions about your future

Lady on the phone, living with coordinating care for her parkinson's disease

Man in a park, living with a lewy body dementia diagnosis

Man outside on the cusp of an age bracket where mild cognitive impairment may appear.

Lady with a cup of tea, reflecting on the early signs of Alzheimer's disease.

Here’s How it Works

A simple three-step process that delivers clear biological answers.

Step 1

Once the test is ordered by a physician, CSF is collected via a routine lumbar puncture procedure. The CSF sample is sent to the Amprion lab.

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Step 2

The SAAmplify assay detects the presence or absence of as few as 10 misfolded ɑ-synuclein molecules in the sample. Results are provided to the physician, who reviews them with the patient.

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Step 3

Clear detected/not detected results help confirm or rule out ɑ-synuclein pathology, with results that correlate to autopsy findings with unprecedented accuracy.

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Resources & Documentation

Access everything you need to include the SAAmplify-ɑSYN (formerly SYNTap®) test into your diagnostic workflow. Our comprehensive resources provide detailed technical specifications, intellectual property information, answers to common questions, and all necessary forms to seamlessly integrate our testing into your clinical workflow.

SAAmplify-αSYN Test Spec Sheet

Complete technical specifications and performance data for the SAAmplify-ɑSYN Test.

Patent Information

Details on Amprion's intellectual property and protected methodology.

FAQs

Answers to common clinical and technical questions about SAAmplify testing.

Forms & Downloads

Download all necessary documentation to order and submit your test.

Get in the Know

Bring biological certainty to your diagnosis with Amprion's SAAmplify-ɑSYN test. Order your shipping kits today and help move your patient beyond a probable diagnosis.